|
.. , .. , .. , .. , ..
...
()
(5 ) : ( 1), ( 2), ( 1), ( 1). , , - . 3- .
4- ( 3- ), , , . - 6 , . (IQ 87 .). : - 0,2 /, - 1,2 /.
2 ( 5 12 ). - 3- , - 90- 97- . : , <> , , . . ( ) (2,5 5,5 / - ; 1,3 2,1 / ).
12 . . - 3- , - 97- . , , . (3,5 /), - 2 /.
- , 4 . : ( 3- ) - 90- . - : , , , . (IQ 92 .). (2 / 2,8 / - ).
-D- - - , . , .
5 10-12 -D- . : - 3- ; - 3 (25-75 ), 2 ( 97- ). IQ 90-105 . ( 85-115 .). 5 -D- - : ( 0,56 / 0,7-1,6 /) ( 500-700 / 30-400 /). ( 50-55 / 19-31 /) (0,7-1 / 1,5-4 /).
( ) 1,5-2 4-7,5 / , -D- . , , , , , , .
, 17 6 ( 3 - - , 2 - , 1 - ). 11 . -D- .
- , , .
17 (. . 1). (7-8 ) - , . 3-4 , , - - . -D- 2- 2,5 .
| 1. |
| |
|
|
|
| 7-8 |
3-4 |
2-2,5 |
3-4 |
1,5-2 |
|
| : , -, K |
6 |
5 |
1 |
0 |
5 |
1 |
0 |
| - - |
1 |
0 |
1 |
0 |
0 |
1 |
0 |
| : , , , |
5 |
1 |
4 |
0 |
0 |
5 |
|
| - -D- |
5 |
0 |
0 |
5 |
0 |
0 |
5 |
(. . 1). (3-4 ) - , 3- . -D- , , . 1,5-2 .
, 2 , , 2 2,5 . , ( , , ), ( , , ).
, , .
17 , , - , , , , . <> .
, N3-2000, .43-46
1. .. : , , . 1994; 80.
2. Goldstein S.J., Shprintzen R.J., Wu R.H. et al. Achondroplasia and obstructive sleep apnea: correction of apnea and abnormal sleepentrained growth hormone release by tracheostomy. Birth Defects Orig Artic Ser 1985; 21: 2: 93-101.
3. Galasso C., Scire G., Boscherini B. Growth hormone and dysmorphic syndromes. Horm Res 1995; 44: Suppl 3: 42-48.
4. Seikaly M., Brown R., Baum M. The Effects of Recombinant Human Growth Hormone in Children With X-Linked Hypophosphatemia. Pediatrics 1997; 100: 5: 879-884.
5. Municchi G., Pasquino A.M., Pucarelli I. et al. Growth hormone treatment in Noonan syndrome: report of four cases who reached final height. Horm Res 1995; 44: 4: 164-167.
6. Hirano T., Izumi I., Tamura K. Growth hormone deficiency in Dubowitz syndrome. Acta Paediatr J 1996; 38: 3: 267-269.
7. Cara J.F., Johanson A.J. Growth hormone deficiency in a girl with the Cohen syndrome. J Med Genet 1991; 28: 1: 48-50.
8. Massa G. Growth hormone deficiency in the Rothmund-Thomson syndrome. Am J Med Genet 1986; 23: 4: 861-868.
9. Kaufman S. Growth hormone deficiency in the Rothmund-Thomson syndrome. Am J Med Genet 1986; 23: 4: 861-868.
10. Stanhope R., Albanese A., Azcona C. Growth hormone treatment of russel-silver syndrome. Horm Res 1998; 49: (Suppl 2): 37-40. 11. Azcona C., Albanese A., Bareille P., Stanhope R. Growth hormone treatment in growth hormone-sufficient and -insufficient children with intrauterine growth retardation. Russell Silver syndrome. Horm Res 1998; 50: 1: 22-27.
12. Azcona C., Stanhope R. Absence of Catch-Down Growth in Russell-Silver Syndrome after Short-Term Growth Hormone Treatment.
Horm Res 1999; 51: 1: 47-49.
|